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KMID : 0376219920290020241
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Chonnam Medical Journal
1992 Volume.29 No. 2 p.241 ~ p.246
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Effect of recombinant human granulocyte-colony stimulating factor on the small cell lung cancer chemotherapy
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Kim Hyeoung-Joon
Bae Youl
Lee Dae-Ho
Choi In-Seon
Park Kyung-Ok
Kook Hoon
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Abstract
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The neutropenia and its ensuing infections are one of the most troublesome, and sometimes fatal, but inevitable complications in the modern aggressive chemotherapy in patients with various cancer. Recombinant human ranulocyte-colony stimulating Factor (rh G-CSF) was introduced as a measure tol shorten the neutropenic period.
We conducted a prospective, phase III clinical study of rh G-CSF in 13 patients with small cell lung cancer. First VAP cycle (etoposide, adriamycin, cisplatin) was followed by 2nd VAP with rh G-CSF four weeks later. Daily 75㎍of rh G-CSF was
given subcutaneously for 14 days starting 72h after the 2nd VAP. The rh G-CSF cycle showed a mean of 3.0 day of grade 3 neutropenia in contrast to 7.1 day in control group (P<0.0001). As a possible side effect, fever was noted in 4, all were readily under control with supportive measures. rh G-CSF-showed clear advantage in reducing the neutropenic period following chemotherapy in patients with small cell lung cancer. Better disease control and survival may be expected by this rh G-CSF combination with chemotherapy, which enables more aggressive therapeutic regimen.
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KEYWORD
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